2HA6

Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine

2HA6 の概要

• エントリーDOI: 10.2210/pdb2ha6/pdb
• 関連するPDBエントリー: 1J06 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA7
• 分子名称: Acetylcholinesterase, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), HEXAETHYLENE GLYCOL, ... (5 entities in total)
• 機能のキーワード: hydrolase fold, serine esterase, acetylcholinesterase, mutant, homodimer, glycosylated protein, hydrolase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121000.96

構造登録者

Bourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P. (登録日: 2006-06-12, 公開日: 2006-07-18, 最終更新日: 2023-10-25)

• 主引用文献: Bourne, Y.,Radic, Z.,Sulzenbacher, G.,Kim, E.,Taylor, P.,Marchot, P.; Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding; J.Biol.Chem., 281:29256-29267, 2006; PubMed: 16837465; DOI: 10.1074/jbc.M603018200

実験手法

X-RAY DIFFRACTION (2.25 Å)