2H9H
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors
2H9H の概要
エントリーDOI | 10.2210/pdb2h9h/pdb |
関連するPDBエントリー | 1HAV 1QA7 2A4O 2CXV 2H6M |
関連するBIRD辞書のPRD_ID | PRD_000423 |
分子名称 | Hepatitis A virus protease 3C, Three residue peptide, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, ... (4 entities in total) |
機能のキーワード | methylketone, episulfide, hydrolase-hydrlase inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Hepatitis A virus |
細胞内の位置 | Protein VP2: Virion (By similarity). Protein VP3: Virion (By similarity). Protein VP1: Virion (By similarity). Protein VP1-2A: Virion (By similarity). Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3ABC: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P06441 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 23983.64 |
構造登録者 | Yin, J.,Cherney, M.M.,Bergmann, E.M.,James, M.N. (登録日: 2006-06-09, 公開日: 2006-08-08, 最終更新日: 2023-08-30) |
主引用文献 | Yin, J.,Cherney, M.M.,Bergmann, E.M.,Zhang, J.,Huitema, C.,Pettersson, H.,Eltis, L.D.,Vederas, J.C.,James, M.N. An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors. J.Mol.Biol., 361:673-686, 2006 Cited by PubMed: 16860823DOI: 10.1016/j.jmb.2006.06.047 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.39 Å) |
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