2H8H

Src kinase in complex with a quinazoline inhibitor

2H8H の概要

• エントリーDOI: 10.2210/pdb2h8h/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE (3 entities in total)
• 機能のキーワード: src kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P12931
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60397.38

構造登録者

Otterbein, L.R.,Norman, R.,Pauptit, R.A.,Rowsell, S.,Breed, J. (登録日: 2006-06-07, 公開日: 2006-11-21, 最終更新日: 2024-04-03)

• 主引用文献: Hennequin, L.F.,Allen, J.,Breed, J.,Curwen, J.,Fennell, M.,Green, T.P.,Lambert-van der Brempt, C.,Morgentin, R.,Norman, R.A.,Olivier, A.,Otterbein, L.,Ple, P.A.,Warin, N.,Costello, G.; N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.; J.Med.Chem., 49:6465-6488, 2006; PubMed: 17064066; DOI: 10.1021/jm060434q

実験手法

X-RAY DIFFRACTION (2.2 Å)