2H7Y

Pikromycin Thioesterase with covalent affinity label

Summary for 2H7Y

• Entry DOI: 10.2210/pdb2h7y/pdb
• Related: 1MNA 2H7X
• Descriptor: Type I polyketide synthase PikAIV, SULFATE ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: thioesterase, alpha/beta hydrolase, hydrolase
• Biological source: Streptomyces venezuelae
• Total number of polymer chains: 2
• Total formula weight: 68432.70

Authors

Giraldes, J.W.,Akey, D.L.,Kittendorf, J.D.,Sherman, D.H.,Smith, J.S.,Fecik, R.A. (deposition date: 2006-06-06, release date: 2006-09-19, Last modification date: 2023-08-30)

• Primary citation: Giraldes, J.W.,Akey, D.L.,Kittendorf, J.D.,Sherman, D.H.,Smith, J.S.,Fecik, R.A.; Structural and Mechanistic Insights of Polyketide Macrolactonization from Polyketide-based Affinity Labels; NAT.CHEM.BIOL., 2:531-536, 2006; PubMed: 16969373; DOI: 10.1038/nchembio822

Experimental method

X-RAY DIFFRACTION (2.1 Å)