2H6I
W102T/Y365F Protein Farnesyltransferase Double Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 3.0A
Summary for 2H6I
Entry DOI | 10.2210/pdb2h6i/pdb |
Related | 1FPP 1JCQ 1KZP 1N4R 1TN8 2H6F 2H6G 2H6H |
Related PRD ID | PRD_900003 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, farnesylated peptide, ... (7 entities in total) |
Functional Keywords | ftase, farnesyltransferase, farnesyl transferase, prenyltransferase, caax, ras, lipid modification, prenylation, substrate selectivity, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 95346.48 |
Authors | Terry, K.L.,Beese, L.S. (deposition date: 2006-05-31, release date: 2006-08-29, Last modification date: 2023-08-30) |
Primary citation | Terry, K.L.,Casey, P.J.,Beese, L.S. Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry, 45:9746-9755, 2006 Cited by PubMed: 16893176DOI: 10.1021/bi060295e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report