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2H65

Crystal strusture of caspase-3 with inhibitor Ac-VDVAD-Cho

Summary for 2H65
Entry DOI10.2210/pdb2h65/pdb
Related2H5I 2H5J
Related PRD IDPRD_000425
Descriptorcaspase-3, p17 subunit, caspase-3, p12 subunit, Ac-VDVAD-Cho, ... (4 entities in total)
Functional Keywordsenzyme catalysis, cysteine protease, apoptosis, induced fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P42574 P42574
Total number of polymer chains6
Total formula weight56624.70
Authors
Fang, B.,Boross, P.I.,Tozser, J.,Weber, I.T. (deposition date: 2006-05-30, release date: 2006-09-19, Last modification date: 2023-11-15)
Primary citationFang, B.,Boross, P.I.,Tozser, J.,Weber, I.T.
Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition
J.Mol.Biol., 360:654-666, 2006
Cited by
PubMed: 16781734
DOI: 10.1016/j.jmb.2006.05.041
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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