2H65
Crystal strusture of caspase-3 with inhibitor Ac-VDVAD-Cho
Summary for 2H65
Entry DOI | 10.2210/pdb2h65/pdb |
Related | 2H5I 2H5J |
Related PRD ID | PRD_000425 |
Descriptor | caspase-3, p17 subunit, caspase-3, p12 subunit, Ac-VDVAD-Cho, ... (4 entities in total) |
Functional Keywords | enzyme catalysis, cysteine protease, apoptosis, induced fit, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P42574 P42574 |
Total number of polymer chains | 6 |
Total formula weight | 56624.70 |
Authors | Fang, B.,Boross, P.I.,Tozser, J.,Weber, I.T. (deposition date: 2006-05-30, release date: 2006-09-19, Last modification date: 2023-11-15) |
Primary citation | Fang, B.,Boross, P.I.,Tozser, J.,Weber, I.T. Structural and kinetic analysis of caspase-3 reveals role for s5 binding site in substrate recognition J.Mol.Biol., 360:654-666, 2006 Cited by PubMed: 16781734DOI: 10.1016/j.jmb.2006.05.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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