2H51
Crystal structure of human caspase-1 (Glu390->Asp and Arg286->Lys) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Summary for 2H51
Entry DOI | 10.2210/pdb2h51/pdb |
Related | 1SC3 2FQQ 2FQR 2FQS 2FQU 2FQV 2H44 2H48 2H4W 2H54 |
Related PRD ID | PRD_000338 |
Descriptor | Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide, ... (4 entities in total) |
Functional Keywords | allosteric site, dimer interface, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P29466 P29466 |
Total number of polymer chains | 3 |
Total formula weight | 30558.46 |
Authors | Scheer, J.M.,Wells, J.A.,Romanowski, M.J. (deposition date: 2006-05-25, release date: 2008-03-11, Last modification date: 2023-08-30) |
Primary citation | Datta, D.,Scheer, J.M.,Romanowski, M.J.,Wells, J.A. An allosteric circuit in caspase-1. J.Mol.Biol., 381:1157-1167, 2008 Cited by PubMed: 18590738DOI: 10.1016/j.jmb.2008.06.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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