2H31

Crystal structure of human PAICS, a bifunctional carboxylase and synthetase in purine biosynthesis

Summary for 2H31

Entry DOI	10.2210/pdb2h31/pdb
Descriptor	Multifunctional protein ADE2, CARBON DIOXIDE (3 entities in total)
Functional Keywords	alpha-beta-alpha, ligase, lyase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	47507.38
Authors	Li, S.-X.,Tong, Y.-P.,Xie, X.-C.,Li, S.-G.,Bi, R.-C. (deposition date: 2006-05-21, release date: 2007-01-30, Last modification date: 2011-07-13)
Primary citation	Li, S.X.,Tong, Y.P.,Xie, X.C.,Wang, Q.H.,Zhou, H.N.,Han, Y.,Zhang, Z.Y.,Gao, W.,Li, S.G.,Zhang, X.C.,Bi, R.C. Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis. J.Mol.Biol., 366:1603-1614, 2007 Cited by PubMed: 17224163 DOI: 10.1016/j.jmb.2006.12.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation