2GYP

Diabetes mellitus due to a frustrated Schellman motif in HNF-1a

Summary for 2GYP

• Entry DOI: 10.2210/pdb2gyp/pdb
• Related: 1JB6 1g2y 1g2z 1g39
• Descriptor: Hepatocyte nuclear factor 1-alpha (2 entities in total)
• Functional Keywords: energy landscape, gene regulation, protein engineering, protein stability, protein structure, transcription regulator
• Total number of polymer chains: 2
• Total formula weight: 7138.30

Authors

Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A. (deposition date: 2006-05-09, release date: 2007-03-20, Last modification date: 2023-11-15)

• Primary citation: Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A.; Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.; J.Mol.Biol., 362:414-429, 2006; PubMed: 16930618; DOI: 10.1016/j.jmb.2006.06.086

Experimental method

X-RAY DIFFRACTION (1.4 Å)