2GVJ
Crystal Structure of Human NMPRTase in complex with FK866
Summary for 2GVJ
Entry DOI | 10.2210/pdb2gvj/pdb |
Related | 2GVG |
Descriptor | Nicotinamide phosphoribosyltransferase, (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide (3 entities in total) |
Functional Keywords | nmprtase, visfatin, pbef, cancer, fk866, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 112254.25 |
Authors | Khan, J.A.,Tao, X.,Tong, L. (deposition date: 2006-05-02, release date: 2006-06-20, Last modification date: 2016-11-09) |
Primary citation | Khan, J.A.,Tao, X.,Tong, L. Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents. Nat.Struct.Mol.Biol., 13:582-588, 2006 Cited by PubMed: 16783377DOI: 10.1038/nsmb1105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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