2GVJ
Crystal Structure of Human NMPRTase in complex with FK866
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 491 | 55735.6 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (human) | NAmPRTase, Nampt, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1, Visfatin |
| 2 | C, D (A, B) | (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide | non-polymer | 391.5 | 2 | Chemie (DGB) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 775 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Mse 1 | Met 1 | modified residue |
| Mse 368 | Met 368 | modified residue |
| Mse 372 | Met 372 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111471.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 783.0 | |
| All* | Total formula weight | 112254.3 |
