2GVF
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
Summary for 2GVF
Entry DOI | 10.2210/pdb2gvf/pdb |
Related | 1A1R 1RGQ 2A4G 2A4Q 2A4R 2FM2 |
Descriptor | polyprotein, Polyprotein, ZINC ION, ... (5 entities in total) |
Functional Keywords | hepatitis c, protease, ketoamide inhibitor, hydrolase |
Biological source | Hepatitis C virus More |
Total number of polymer chains | 4 |
Total formula weight | 47911.88 |
Authors | Arasappan, A.,Njoroge, F.G.,Chen, K.X.,Venkatraman, S.,Parekh, T.N.,Gu, H.,Pichardo, J.,Butkiewicz, N.,Prongay, A.,Madison, V.,Girijavallabhan, V. (deposition date: 2006-05-02, release date: 2007-01-23, Last modification date: 2011-07-13) |
Primary citation | Arasappan, A.,Njoroge, F.G.,Chen, K.X.,Venkatraman, S.,Parekh, T.N.,Gu, H.,Pichardo, J.,Butkiewicz, N.,Prongay, A.,Madison, V.,Girijavallabhan, V. P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorg.Med.Chem.Lett., 16:3960-3965, 2006 Cited by PubMed: 16730985DOI: 10.1016/j.bmcl.2006.05.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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