2GTM

Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579

Summary for 2GTM

Entry DOI	10.2210/pdb2gtm/pdb
Related	1yw2 1ywr 2ghl 2ghm
Descriptor	Mitogen-activated protein kinase 14, 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM (3 entities in total)
Functional Keywords	map kinase p38, p38, transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm : P47811
Total number of polymer chains	1
Total formula weight	40301.47
Authors	Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Sabat, M. (deposition date: 2006-04-28, release date: 2006-05-23, Last modification date: 2024-04-03)
Primary citation	Sabat, M.,Vanrens, J.C.,Clark, M.P.,Brugel, T.A.,Maier, J.,Bookland, R.G.,Laufersweiler, M.J.,Laughlin, S.K.,Golebiowski, A.,De, B.,Hsieh, L.C.,Walter, R.L.,Mekel, M.J.,Janusz, M.J. The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16:4360-4365, 2006 Cited by PubMed: 16750367 DOI: 10.1016/j.bmcl.2006.05.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation