2GSE

Crystal Structure of Human Dihydropyrimidinease-like 2

2GSE の概要

• エントリーDOI: 10.2210/pdb2gse/pdb
• 分子名称: Dihydropyrimidinase-related protein 2, CALCIUM ION (3 entities in total)
• 機能のキーワード: alpha/beta barrel, structural genomics, structural genomics consortium, sgc, dihydropyrimidinase-related protein 2, drp2, collapsin response mediator protein 2, crmp2, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : Q16555
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 220548.19

構造登録者

Ogg, D.,Stenmark, P.,Arrowsmith, C.,Berglund, H.,Collins, R.,Edwards, A.,Ehn, M.,Flodin, S.,Flores, A.,Graslund, S.,Hallberg, B.M.,Hammarstrom, M.,Kotenyova, T.,Kursula, P.,Nilsson-Ehle, P.,Nyman, T.,Persson, C.,Sagemark, J.,Sundstrom, M.,Holmberg-Schiavone, L.,Thorsell, A.G.,Uppenberg, J.,Van Den Berg, S.,Weigelt, J.,Nordlund, P.,Structural Genomics Consortium (SGC) (登録日: 2006-04-26, 公開日: 2006-05-09, 最終更新日: 2024-02-14)

主引用文献

Stenmark, P.,Ogg, D.,Flodin, S.,Flores, A.,Kotenyova, T.,Nyman, T.,Nordlund, P.,Kursula, P.
The structure of human collapsin response mediator protein 2, a regulator of axonal growth.
J.Neurochem., 101:906-917, 2007

PubMed Abstract: Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers.

PubMed: 17250651
DOI: 10.1111/j.1471-4159.2006.04401.x

実験手法

X-RAY DIFFRACTION (2.4 Å)