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2GM1

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide

Summary for 2GM1
Entry DOI10.2210/pdb2gm1/pdb
DescriptorKINESIN-RELATED MOTOR PROTEIN EG5, MAGNESIUM ION, N-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE, ... (5 entities in total)
Functional Keywordseg5 mg-adp complex inhibitor, cell cycle
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P52732
Total number of polymer chains4
Total formula weight168141.66
Authors
Sheriff, S. (deposition date: 2006-04-05, release date: 2006-06-27, Last modification date: 2024-02-14)
Primary citationKim, K.S.,Lu, S.,Cornelius, L.A.,Lombardo, L.J.,Borzilleri, R.M.,Schroeder, G.M.,Sheng, C.,Rovnyak, G.,Crews, D.,Schmidt, R.J.,Williams, D.K.,Bhide, R.S.,Traeger, S.C.,McDonnell, P.A.,Mueller, L.,Sheriff, S.,Newitt, J.A.,Pudzianowski, A.T.,Yang, Z.,Wild, R.,Lee, F.Y.,Batorsky, R.,Ryder, J.S.,Ortega-Nanos, M.,Shen, H.,Gottardis, M.,Roussell, D.L.
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
Bioorg.Med.Chem.Lett., 16:3937-3942, 2006
Cited by
PubMed: 16730979
DOI: 10.1016/j.bmcl.2006.05.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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