2GM1

Crystal structure of the mitotic kinesin eg5 in complex with mg-adp and n-(3-aminopropyl)-n-((3-benzyl-5-chloro-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide

2GM1 の概要

• エントリーDOI: 10.2210/pdb2gm1/pdb
• 分子名称: KINESIN-RELATED MOTOR PROTEIN EG5, MAGNESIUM ION, N-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE, ... (5 entities in total)
• 機能のキーワード: eg5 mg-adp complex inhibitor, cell cycle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P52732
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 168141.66

構造登録者

Sheriff, S. (登録日: 2006-04-05, 公開日: 2006-06-27, 最終更新日: 2024-04-03)

• 主引用文献: Kim, K.S.,Lu, S.,Cornelius, L.A.,Lombardo, L.J.,Borzilleri, R.M.,Schroeder, G.M.,Sheng, C.,Rovnyak, G.,Crews, D.,Schmidt, R.J.,Williams, D.K.,Bhide, R.S.,Traeger, S.C.,McDonnell, P.A.,Mueller, L.,Sheriff, S.,Newitt, J.A.,Pudzianowski, A.T.,Yang, Z.,Wild, R.,Lee, F.Y.,Batorsky, R.,Ryder, J.S.,Ortega-Nanos, M.,Shen, H.,Gottardis, M.,Roussell, D.L.; Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.; Bioorg.Med.Chem.Lett., 16:3937-3942, 2006; PubMed: 16730979; DOI: 10.1016/j.bmcl.2006.05.037

実験手法

X-RAY DIFFRACTION (2.3 Å)