2GLW
The solution structure of PHS018 from pyrococcus horikoshii
Summary for 2GLW
| Entry DOI | 10.2210/pdb2glw/pdb |
| NMR Information | BMRB: 7116 |
| Descriptor | 92aa long hypothetical protein (1 entity in total) |
| Functional Keywords | rift barrel, bioinformatics, transcription |
| Biological source | Pyrococcus horikoshii |
| Total number of polymer chains | 1 |
| Total formula weight | 10302.03 |
| Authors | Coles, M.,Hulko, M.,Truffault, V.,Martin, J.,Lupas, A.N. (deposition date: 2006-04-05, release date: 2006-12-05, Last modification date: 2024-05-01) |
| Primary citation | Coles, M.,Hulko, M.,Djuranovic, S.,Truffault, V.,Koretke, K.,Martin, J.,Lupas, A.N. Common evolutionary origin of swapped-hairpin and double-psi beta barrels Structure, 14:1489-1498, 2006 Cited by PubMed Abstract: The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels. PubMed: 17027498DOI: 10.1016/j.str.2006.08.005 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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