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2GJ4

Structure of rabbit muscle glycogen phosphorylase in complex with ligand

2GJ4 の概要
エントリーDOI10.2210/pdb2gj4/pdb
分子名称Glycogen phosphorylase, muscle form, SULFATE ION, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, ... (5 entities in total)
機能のキーワードglycogen phosphorylase, transferase
由来する生物種Oryctolagus cuniculus (rabbit)
タンパク質・核酸の鎖数1
化学式量合計96544.30
構造登録者
Otterbein, L.R.,Pannifer, A.D.,Tucker, J.,Breed, J.,Oikonomakos, N.G.,Rowsell, S.,Pauptit, R.A.,Claire, M. (登録日: 2006-03-30, 公開日: 2007-02-13, 最終更新日: 2024-10-16)
主引用文献Whittamore, P.R.,Addie, M.S.,Bennett, S.N.,Birch, A.M.,Butters, M.,Godfrey, L.,Kenny, P.W.,Morley, A.D.,Murray, P.M.,Oikonomakos, N.G.,Otterbein, L.R.,Pannifer, A.D.,Parker, J.S.,Readman, K.,Siedlecki, P.S.,Schofield, P.,Stocker, A.,Taylor, M.J.,Townsend, L.A.,Whalley, D.P.,Whitehouse, J.
Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies.
Bioorg.Med.Chem.Lett., 16:5567-5571, 2006
Cited by
PubMed Abstract: Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.
PubMed: 16945526
DOI: 10.1016/j.bmcl.2006.08.047
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.6 Å)
構造検証レポート
Validation report summary of 2gj4
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-27に公開中

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