2GIQ

Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-2 inhibitor

2GIQ の概要

• エントリーDOI: 10.2210/pdb2giq/pdb
• 分子名称: RNA-directed RNA polymerase, 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE (3 entities in total)
• 機能のキーワード: hcv, hepatitis, ns5b, transferase, rna-dependent rna polymerase
• 由来する生物種: Hepatitis C virus (isolate BK)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127354.01

構造登録者

Harris, S.F. (登録日: 2006-03-29, 公開日: 2007-04-03, 最終更新日: 2024-02-14)

• 主引用文献: Le Pogam, S.,Kang, H.,Harris, S.F.,Leveque, V.,Giannetti, A.M.,Ali, S.,Jiang, W.R.,Rajyaguru, S.,Tavares, G.,Oshiro, C.,Hendricks, T.,Klumpp, K.,Symons, J.,Browner, M.F.,Cammack, N.,Najera, I.; Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.; J.Virol., 80:6146-6154, 2006; PubMed: 16731953; DOI: 10.1128/JVI.02628-05

実験手法

X-RAY DIFFRACTION (1.65 Å)