2GEE
Crystal Structure of Human Type III Fibronectin Extradomain B and Domain 8
Summary for 2GEE
| Entry DOI | 10.2210/pdb2gee/pdb |
| Related | 1fnf 2fnb |
| Descriptor | hypothetical protein (2 entities in total) |
| Functional Keywords | fibronectin, eiiib, cancer, neovascularization, cell adhesion, protein binding, oncoprotein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 22097.48 |
| Authors | Bencharit, S.,Cui, C.B.,Siddiqui, A.,Howard-Williams, E.L.,Aukhil, I. (deposition date: 2006-03-19, release date: 2006-10-17, Last modification date: 2023-08-30) |
| Primary citation | Bencharit, S.,Cui, C.B.,Siddiqui, A.,Howard-Williams, E.L.,Sondek, J.,Zuobi-Hasona, K.,Aukhil, I. Structural insights into fibronectin type III domain-mediated signaling. J.Mol.Biol., 367:303-309, 2007 Cited by PubMed Abstract: The alternatively spliced type III extradomain B (EIIIB) of fibronectin (FN) is expressed only during embryogenesis, wound healing and tumorigenesis. The biological function of this domain is unclear. We describe here the first crystal structure of the interface between alternatively spliced EIIIB and its adjacent FN type III domain 8 (FN B-8). The opened CC' loop of EIIIB, and the rotation and tilt of EIIIB allow good access to the FG loop of FN-8, which is normally hindered by the CC' loop of FN-7. In addition, the AGEGIP sequence of the CC'' loop of EIIIB replaces the NGQQGN sequence of the CC' loop of FN-7. Finally, the CC'' loop of EIIIB forms an acidic groove with FN-8. These structural findings warrant future studies directed at identifying potential binding partners for FN B-8 interface, linking EIIIB to skeletal and cartilaginous development, wound healing, and tumorigenesis, respectively. PubMed: 17261313DOI: 10.1016/j.jmb.2006.10.017 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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