2GDO

4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors

2GDO の概要

• エントリーDOI: 10.2210/pdb2gdo/pdb
• 分子名称: Serine/threonine-protein kinase Chk1, SULFATE ION, 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE, ... (4 entities in total)
• 機能のキーワード: drug design, atp-binding, cell cycle, dna damage, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: O14757
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34483.89

構造登録者

Le, V.,Dove, J.,Fang, E.,Bussiere, D.E. (登録日: 2006-03-16, 公開日: 2007-03-20, 最終更新日: 2024-02-14)

主引用文献

Ni, Z.J.,Barsanti, P.,Brammeier, N.,Diebes, A.,Poon, D.J.,Ng, S.,Pecchi, S.,Pfister, K.,Renhowe, P.A.,Ramurthy, S.,Wagman, A.S.,Bussiere, D.E.,Le, V.,Zhou, Y.,Jansen, J.M.,Ma, S.,Gesner, T.G.
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.
Bioorg.Med.Chem.Lett., 16:3121-3124, 2006

PubMed Abstract: CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.

PubMed: 16603354
DOI: 10.1016/j.bmcl.2006.03.059

実験手法

X-RAY DIFFRACTION (3 Å)