2GD2

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

2GD2 の概要

• エントリーDOI: 10.2210/pdb2gd2/pdb
• 関連するPDBエントリー: 1X74 2GCE 2GCI 2GD0 2GD6
• 分子名称: probable alpha-methylacyl-CoA racemase MCR, ACETOACETYL-COENZYME A, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: alpha-methylacyl-coa racemase, racemase, coa transferase, proton transfer, coenzyme a, isomerase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 158481.82

構造登録者

Bhaumik, P.,Wierenga, R.K. (登録日: 2006-03-15, 公開日: 2007-02-20, 最終更新日: 2023-10-25)

• 主引用文献: Bhaumik, P.,Schmitz, W.,Hassinen, A.,Hiltunen, J.K.,Conzelmann, E.,Wierenga, R.K.; The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface; J.Mol.Biol., 367:1145-1161, 2007; PubMed: 17320106; DOI: 10.1016/j.jmb.2007.01.062

実験手法

X-RAY DIFFRACTION (1.7 Å)