2GC8
Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase
Summary for 2GC8
| Entry DOI | 10.2210/pdb2gc8/pdb |
| Descriptor | RNA-directed RNA polymerase, 1-[(2-AMINO-4-CHLORO-5-METHYLPHENYL)SULFONYL]-L-PROLINE (3 entities in total) |
| Functional Keywords | transferase |
| Biological source | Hepatitis C virus |
| Total number of polymer chains | 2 |
| Total formula weight | 129132.75 |
| Authors | Gopalsamy, A.,Chopra, R.,Lim, K.,Ciszewski, G.,Shi, M.,Curran, K.J.,Sukits, S.F.,Svenson, K.,Bard, J.,Ellingboe, J.W.,Agarwal, A.,Krishnamurthy, G.,Howe, A.Y.,Orlowski, M.,Feld, B.,O'connell, J.,Mansour, T.S. (deposition date: 2006-03-13, release date: 2006-06-13, Last modification date: 2023-08-30) |
| Primary citation | Gopalsamy, A.,Chopra, R.,Lim, K.,Ciszewski, G.,Shi, M.,Curran, K.J.,Sukits, S.F.,Svenson, K.,Bard, J.,Ellingboe, J.W.,Agarwal, A.,Krishnamurthy, G.,Howe, A.Y.,Orlowski, M.,Feld, B.,O'connell, J.,Mansour, T.S. Discovery of Proline Sulfonamides as Potent and Selective Hepatitis C Virus NS5b Polymerase Inhibitors. Evidence for a New NS5b Polymerase Binding Site. J.Med.Chem., 49:3052-3055, 2006 Cited by PubMed: 16722622DOI: 10.1021/jm060168g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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