2GBI

rat DPP-IV with xanthine inhibitor 4

Summary for 2GBI

Entry DOI	10.2210/pdb2gbi/pdb
Related	2GBC 2GBF 2GBG
Descriptor	Dipeptidyl peptidase 4, 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE (2 entities in total)
Functional Keywords	serine peptidase beta propeller, hydrolase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P14740
Total number of polymer chains	2
Total formula weight	169068.60
Authors	Longenecker, K.L.,Jakob, C.G.,Fry, E.H.,Wilk, S. (deposition date: 2006-03-10, release date: 2006-07-04, Last modification date: 2017-10-18)
Primary citation	Longenecker, K.L.,Stewart, K.D.,Madar, D.J.,Jakob, C.G.,Fry, E.H.,Wilk, S.,Lin, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Yong, H.,Pireh, D.,Pei, Z.,Basha, F.,Wiedeman, P.E.,Von Geldern, T.W.,Trevillyan, J.M.,Stoll, V.S. Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors. Biochemistry, 45:7474-7482, 2006 Cited by PubMed: 16768443 DOI: 10.1021/bi060184f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation