2GBG

rat DPP-IV with alkynyl cyanopyrrolidine #2

2GBG の概要

関連するPDBエントリー2GBC 2GBF
分子名称Dipeptidyl peptidase 4, SULFATE ION, (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE (3 entities in total)
機能のキーワードserine peptidase beta propeller, hydrolase
由来する生物種Rattus norvegicus (Norway rat)
細胞内の位置Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein P14740
ポリマー鎖数2
分子量合計169034.6
構造登録者
Longenecker, K.L.,Jakob, C.G.,Fry, E.H.,Wilk, S. (登録日: 2006-03-10, 公開日: 2006-07-04, 最終更新日: 2017-10-18)
主引用文献
Longenecker, K.L.,Stewart, K.D.,Madar, D.J.,Jakob, C.G.,Fry, E.H.,Wilk, S.,Lin, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Yong, H.,Pireh, D.,Pei, Z.,Basha, F.,Wiedeman, P.E.,Von Geldern, T.W.,Trevillyan, J.M.,Stoll, V.S.
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors.
Biochemistry, 45:7474-7482, 2006
PubMed: 16768443 (主引用文献が同じPDBエントリー)
DOI: 10.1021/bi060184f
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264243.0%7.9%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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