2G9Z
Thiamin pyrophosphokinase from Candida albicans
Summary for 2G9Z
| Entry DOI | 10.2210/pdb2g9z/pdb |
| Related | 1IG0 |
| Descriptor | thiamine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | thiamin-pnp, tpk, thiamin pyrophosphokinase, structural genomics, profun, bacterial targets at igs-cnrs, france, bigs, transferase |
| Biological source | Candida albicans |
| Total number of polymer chains | 2 |
| Total formula weight | 80871.81 |
| Authors | Abergel, C.,Santini, S.,Monchois, V.,Rousselle, T.,Claverie, J.M.,Bacterial targets at IGS-CNRS, France (BIGS) (deposition date: 2006-03-07, release date: 2006-04-04, Last modification date: 2023-10-25) |
| Primary citation | Santini, S.,Monchois, V.,Mouz, N.,Sigoillot, C.,Rousselle, T.,Claverie, J.M.,Abergel, C. Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase. Bmc Struct.Biol., 8:33-33, 2008 Cited by PubMed Abstract: In search of new antifungal targets of potential interest for pharmaceutical companies, we initiated a comparative genomics study to identify the most promising protein-coding genes in fungal genomes. One criterion was the protein sequence conservation between reference pathogenic genomes. A second criterion was that the corresponding gene in Saccharomyces cerevisiae should be essential. Since thiamine pyrophosphate is an essential product involved in a variety of metabolic pathways, proteins responsible for its production satisfied these two criteria. PubMed: 18652651DOI: 10.1186/1472-6807-8-33 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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