2G9X
Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
Summary for 2G9X
Entry DOI | 10.2210/pdb2g9x/pdb |
Descriptor | Cell division protein kinase 2, Cyclin-A2, 3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine protein kinase, atp-binding, cell cycle, phosphorylation, transferase-cell cycle complex, transferase/cell cycle |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P30274 |
Total number of polymer chains | 4 |
Total formula weight | 129269.56 |
Authors | Echalier, A.,Endicott, J.A.,Noble, M.E. (deposition date: 2006-03-07, release date: 2006-05-23, Last modification date: 2023-08-30) |
Primary citation | Griffin, R.J.,Henderson, A.,Curtin, N.J.,Echalier, A.,Endicott, J.A.,Hardcastle, I.R.,Newell, D.R.,Noble, M.E.,Wang, L.Z.,Golding, B.T. Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination. J.Am.Chem.Soc., 128:6012-6013, 2006 Cited by PubMed: 16669651DOI: 10.1021/ja060595j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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