2G9R
The crystal structure of glycogen phosphorylase b in complex with (3R,4R,5R)-5-hydroxymethyl-1-(3-phenylpropyl)-piperidine-3,4-diol
Summary for 2G9R
Entry DOI | 10.2210/pdb2g9r/pdb |
Related | 2g9q 2g9u 2g9v |
Descriptor | Glycogen phosphorylase, muscle form, (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL (3 entities in total) |
Functional Keywords | glycogen phosphorylase, catalytic site, rational inhibitor design, transferase |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 1 |
Total formula weight | 97784.67 |
Authors | Oikonomakos, N.G.,Tiraidis, C.,Leonidas, D.D.,Zographos, S.E. (deposition date: 2006-03-07, release date: 2007-01-16, Last modification date: 2023-11-15) |
Primary citation | Oikonomakos, N.G.,Tiraidis, C.,Leonidas, D.D.,Zographos, S.E.,Kristiansen, M.,Jessen, C.U.,Norskov-Lauritsen, L.,Agius, L. Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition. J.Med.Chem., 49:5687-5701, 2006 Cited by PubMed: 16970395DOI: 10.1021/jm060496g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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