2G9R

The crystal structure of glycogen phosphorylase b in complex with (3R,4R,5R)-5-hydroxymethyl-1-(3-phenylpropyl)-piperidine-3,4-diol

2G9R の概要

• エントリーDOI: 10.2210/pdb2g9r/pdb
• 関連するPDBエントリー: 2g9q 2g9u 2g9v
• 分子名称: Glycogen phosphorylase, muscle form, (3R,4R,5R)-5-(HYDROXYMETHYL)-1-(3-PHENYLPROPYL)PIPERIDINE-3,4-DIOL (3 entities in total)
• 機能のキーワード: glycogen phosphorylase, catalytic site, rational inhibitor design, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97784.67

構造登録者

Oikonomakos, N.G.,Tiraidis, C.,Leonidas, D.D.,Zographos, S.E. (登録日: 2006-03-07, 公開日: 2007-01-16, 最終更新日: 2023-11-15)

• 主引用文献: Oikonomakos, N.G.,Tiraidis, C.,Leonidas, D.D.,Zographos, S.E.,Kristiansen, M.,Jessen, C.U.,Norskov-Lauritsen, L.,Agius, L.; Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition.; J.Med.Chem., 49:5687-5701, 2006; PubMed: 16970395; DOI: 10.1021/jm060496g

実験手法

X-RAY DIFFRACTION (2.07 Å)