2G89

L. casei thymidylate synthase Y261A in complex with substrate, dUMP

Summary for 2G89

• Entry DOI: 10.2210/pdb2g89/pdb
• Related: 2G86 2G8A 2G8D 2G8M 2G8O
• Descriptor: thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (3 entities in total)
• Functional Keywords: alpha/beta protein, beta sheet, dump-binding residue, dump complex, active site mutation, transferase
• Biological source: Lactobacillus casei
• Cellular location: Cytoplasm : P00469
• Total number of polymer chains: 1
• Total formula weight: 36846.54

Authors

Finer-Moore, J.S.,Stroud, R.M. (deposition date: 2006-03-02, release date: 2006-03-14, Last modification date: 2024-02-14)

• Primary citation: Newby, Z.,Lee, T.T.,Morse, R.J.,Liu, Y.,Liu, L.,Venkatraman, P.,Santi, D.V.,Finer-Moore, J.S.,Stroud, R.M.; The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261; Biochemistry, 45:7415-7428, 2006; PubMed: 16768437; DOI: 10.1021/bi060152s

Experimental method

X-RAY DIFFRACTION (2.5 Å)