2G5R

Crystal structure of Siglec-7 in complex with methyl-9-(aminooxalyl-amino)-9-deoxyNeu5Ac (oxamido-Neu5Ac)

2G5R の概要

• エントリーDOI: 10.2210/pdb2g5r/pdb
• 分子名称: Sialic acid-binding Ig-like lectin 7, 2-acetamido-2-deoxy-beta-D-glucopyranose, methyl 5-acetamido-9-{[amino(oxo)acetyl]amino}-3,5,9-trideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosidonic acid, ... (5 entities in total)
• 機能のキーワード: siglec, sialic acid, sialoside, cell adhesion
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: Q9Y286
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15391.00

構造登録者

Attrill, H.,Crocker, P.R.,van Aalten, D.M. (登録日: 2006-02-23, 公開日: 2006-06-20, 最終更新日: 2023-11-15)

• 主引用文献: Attrill, H.,Takazawa, H.,Witt, S.,Kelm, S.,Isecke, R.,Brossmer, R.,Ando, T.,Ishida, H.,Kiso, M.,Crocker, P.R.,van Aalten, D.M.; The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.; Biochem.J., 397:271-278, 2006; PubMed: 16623661; DOI: 10.1042/BJ20060103

実験手法

X-RAY DIFFRACTION (1.6 Å)