2G50

The location of the allosteric amino acid binding site of muscle pyruvate kinase.

2G50 の概要

• エントリーDOI: 10.2210/pdb2g50/pdb
• 分子名称: Pyruvate kinase isozymes M1/M2, MANGANESE (II) ION, POTASSIUM ION, ... (10 entities in total)
• 機能のキーワード: allostery, pyruvate kinase, glycolysis, kinase, phosphoryl transfer, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Cytoplasm : P11974
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 470798.58

構造登録者

Holyoak, T.,Williams, R.,Fenton, A.W. (登録日: 2006-02-22, 公開日: 2006-05-09, 最終更新日: 2024-04-03)

• 主引用文献: Williams, R.,Holyoak, T.,McDonald, G.,Gui, C.,Fenton, A.W.; Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase.; Biochemistry, 45:5421-5429, 2006; PubMed: 16634623; DOI: 10.1021/bi0524262

実験手法

X-RAY DIFFRACTION (1.65 Å)