2G1N
Ketopiperazine-based renin inhibitors: Optimization of the "C" ring
Summary for 2G1N
Entry DOI | 10.2210/pdb2g1n/pdb |
Related | 2G1O 2G1R 2G1S 2G1Y 2G20 2G21 2G22 2G24 2G26 2G27 |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE, ... (4 entities in total) |
Functional Keywords | protein-ligand complexes, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 74403.92 |
Authors | Holsworth, D.D. (deposition date: 2006-02-14, release date: 2006-06-13, Last modification date: 2020-07-29) |
Primary citation | Holsworth, D.D.,Cai, C.,Cheng, X.M.,Cody, W.L.,Downing, D.M.,Erasga, N.,Lee, C.,Powell, N.A.,Ednunds, J.J.,Stier, M.,Jalaie, M.,Zhang, E.,McConnell, P.,Ryan, M.J.,Bryant, J.,Li, T.,Kasani, A.,Hall, E.,Subedi, R.,Rahim, M.,Maiti, S. Ketopiperazine-based renin inhibitors: Optimization of the "C" ring BIOORG.MED.CHEM.LETT., 16:2500-2504, 2006 Cited by PubMed: 16480874DOI: 10.1016/j.bmcl.2006.01.084 PDB entries with the same primary citation |
Experimental method |
Structure validation
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