2FYO

Crystal structure of rat carnitine palmitoyltransferase 2 in space group P43212

Summary for 2FYO

Entry DOI	10.2210/pdb2fyo/pdb
Related	2DEB 2fw3
Descriptor	Carnitine O-palmitoyltransferase II, mitochondrial (2 entities in total)
Functional Keywords	central six-stranded beta-sheet, transferase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : P18886
Total number of polymer chains	1
Total formula weight	74128.85
Authors	Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (deposition date: 2006-02-08, release date: 2007-02-08, Last modification date: 2024-11-20)
Primary citation	Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment Structure, 14:713-723, 2006 Cited by PubMed Abstract: Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association. PubMed: 16615901 DOI: 10.1016/j.str.2006.01.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation