2FXR

human beta tryptase II complexed with activated ketone inhibitor CRA-29382

Summary for 2FXR

Entry DOI	10.2210/pdb2fxr/pdb
Related	2FWW 2FX4 2FX6
Descriptor	Tryptase beta-2, ALLYL {(1S)-1-[(5-{4-[(2,3-DIHYDRO-1H-INDEN-2-YLAMINO)CARBONYL]BENZYL}-1,2,4-OXADIAZOL-3-YL)CARBONYL]-3-PYRROLIDIN-3-YLPROPYL}CARBAMATE (3 entities in total)
Functional Keywords	serine protease, activated ketone inhibitor, pyrrolidine, cra-29382, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P20231
Total number of polymer chains	4
Total formula weight	112196.26
Authors	Katz, B.A. (deposition date: 2006-02-06, release date: 2006-02-09, Last modification date: 2023-08-30)
Primary citation	McGrath, M.E.,Sprengeler, P.A.,Hirschbein, B.,Somoza, J.R.,Lehoux, I.,Janc, J.W.,Gjerstad, E.,Graupe, M.,Estiarte, A.,Venkataramani, C.,Liu, Y.,Yee, R.,Ho, J.D.,Green, M.J.,Lee, C.-S.,Liu, L.,Tai, V.,Spencer, J.,Sperandio, D.,Katz, B.A. Structure-guided design of Peptide-based tryptase inhibitors. Biochemistry, 45:5964-5973, 2006 Cited by PubMed: 16681368 DOI: 10.1021/bi060173m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation