2FVJ

A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro

Summary for 2FVJ

Entry DOI	10.2210/pdb2fvj/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, Nuclear receptor coactivator 1, 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXY-4-{[4-(2-METHOXYPHENYL)PIPERIDIN-1-YL]METHYL}ISOQUINOLINE, ... (5 entities in total)
Functional Keywords	nuclear receptor lbd, alpha helical sandwich, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P37231 Nucleus (By similarity): Q15788
Total number of polymer chains	2
Total formula weight	33103.48
Authors	Benz, J.,Burgermeister, E.,Flament, A.,Schnoebelen, A.,Stihle, M.,Gsell, B.,Rufer, A.,Ruf, A.,Kuhn, B.,Maerki, H.P.,Mizrahi, J.,Sebokova, E.,Niesor, E.,Meyer, M. (deposition date: 2006-01-31, release date: 2006-05-16, Last modification date: 2024-04-03)
Primary citation	Burgermeister, E.,Schnoebelen, A.,Flament, A.,Benz, J.,Stihle, M.,Gsell, B.,Rufer, A.,Ruf, A.,Kuhn, B.,Maerki, H.P.,Mizrahi, J.,Sebokova, E.,Niesor, E.,Meyer, M. A novel partial agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) recruits PPARgamma-coactivator-1alpha, prevents triglyceride accumulation, and potentiates insulin signaling in vitro Mol.Endocrinol., 20:809-830, 2006 Cited by PubMed: 16373399 DOI: 10.1210/me.2005-0171 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation