2FSE

Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen

Summary for 2FSE

• Entry DOI: 10.2210/pdb2fse/pdb
• Descriptor: H-2 class II histocompatibility antigen, E-K alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Collagen alpha-1(II), ... (4 entities in total)
• Functional Keywords: rheumatoid arthritis, hla-dr1, collagen type ii, antigen presentation, immune system, structural protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Secreted, extracellular space, extracellular matrix : P02458
• Total number of polymer chains: 6
• Total formula weight: 87962.28

Authors

Ivey, R.A.,Rosloniec, E.F.,Whittington, K.B.,Kang, A.H.,Park, H.W. (deposition date: 2006-01-22, release date: 2006-09-19, Last modification date: 2017-10-18)

• Primary citation: Rosloniec, E.F.,Ivey, R.A.,Whittington, K.B.,Kang, A.H.,Park, H.W.; Crystallographic Structure of a Rheumatoid Arthritis MHC Susceptibility Allele, HLA-DR1 (DRB1*0101), Complexed with the Immunodominant Determinant of Human Type II Collagen.; J.Immunol., 177:3884-3892, 2006; PubMed: 16951351

Experimental method

X-RAY DIFFRACTION (3.1 Å)