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2FNT

Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.

Summary for 2FNT
Entry DOI10.2210/pdb2fnt/pdb
Related1TSQ 2FNS
Descriptorprotease, NC-p1 substrate PEPTIDE, ACETATE ION, ... (5 entities in total)
Functional Keywordsstructural intermediate, substrate recognition, hiv-1 protease, nc-p1 substrate, drug resistance, flap conformation, hydrolase
Biological sourceHuman immunodeficiency virus 1
More
Total number of polymer chains3
Total formula weight23482.80
Authors
Prabu-Jeyabaln, M.,Nalivaika, E.A.,Schiffer, C.A. (deposition date: 2006-01-11, release date: 2006-09-05, Last modification date: 2023-08-30)
Primary citationPrabu-Jeyabalan, M.,Nalivaika, E.A.,Romano, K.,Schiffer, C.A.
Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediate.
J.Virol., 80:3607-3616, 2006
Cited by
PubMed: 16537628
DOI: 10.1128/JVI.80.7.3607-3616.2006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.44 Å)
Structure validation

217705

數據於2024-03-27公開中

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