2FNT
Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | protease | polymer | 99 | 10772.7 | 2 | UniProt (O38716) Pfam (PF00077) UniProt (by SIFTS) (P03369) In PDB | Human immunodeficiency virus 1 | Retropepsin, PR |
2 | P | NC-p1 substrate PEPTIDE | polymer | 10 | 1190.4 | 1 | |||
3 | A, B | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
4 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
5 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38716)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 7 | engineered mutation |
Asn 25 | Asp 25 | engineered mutation |
Val 64 | Ile 64 | engineered mutation |
Ala 82 | Val 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 22735.8 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 747.0 | |
All* | Total formula weight | 23482.8 |