2FNT
Crystal structure of a drug-resistant (V82A) inactive (D25N) HIV-1 protease complexed with AP2V variant of HIV-1 NC-p1 substrate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | protease | polymer | 99 | 10772.7 | 2 | UniProt (O38716) Pfam (PF00077) UniProt (by SIFTS) (P03369) | Human immunodeficiency virus 1 | Retropepsin, PR |
| 2 | C (P) | NC-p1 substrate PEPTIDE | polymer | 10 | 1190.4 | 1 | |||
| 3 | D, H, L (A, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 4 | E, F, G, I, J... (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 5 | M, N, O (A, B, P) | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38716)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 7 | engineered mutation |
| Asn 25 | Asp 25 | engineered mutation |
| Val 64 | Ile 64 | engineered mutation |
| Ala 82 | Val 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22735.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 747.0 | |
| All* | Total formula weight | 23482.8 |
