2FLD

I-MsoI Re-Designed for Altered DNA Cleavage Specificity

Summary for 2FLD

• Entry DOI: 10.2210/pdb2fld/pdb
• Related: 1M5X
• Descriptor: 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', DNA ENDONUCLEASE I-MSOI, ... (6 entities in total)
• Functional Keywords: homing endonuclease, dna, hydrolase-dna complex, hydrolase/dna
• Biological source: Monomastix sp.
• Total number of polymer chains: 4
• Total formula weight: 52715.23

Authors

Ashworth, J.,Duarte, C.M.,Havranek, J.J.,Sussman, D.,Monnat, R.J.,Stoddard, B.L.,Baker, D. (deposition date: 2006-01-05, release date: 2006-06-06, Last modification date: 2023-08-30)

• Primary citation: Ashworth, J.,Havranek, J.J.,Duarte, C.M.,Sussman, D.,Monnat, R.J.,Stoddard, B.L.,Baker, D.; Computational redesign of endonuclease DNA binding and cleavage specificity.; Nature, 441:656-659, 2006; PubMed: 16738662; DOI: 10.1038/nature04818

Experimental method

X-RAY DIFFRACTION (2 Å)