2FLB
Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor
Summary for 2FLB
Entry DOI | 10.2210/pdb2flb/pdb |
Related | 1o5d |
Descriptor | Coagulation factor VII, Tissue factor, 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, ... (5 entities in total) |
Functional Keywords | active site-directed, short hydrogen bond-mediated, pyrazole-based inhibitor, hydrolase-blood clotting complex, hydrolase/blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P08709 P08709 Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726 |
Total number of polymer chains | 3 |
Total formula weight | 70208.00 |
Authors | Katz, B.A. (deposition date: 2006-01-05, release date: 2006-04-04, Last modification date: 2017-10-11) |
Primary citation | Vijaykumar, D.,Sprengeler, P.A.,Shaghafi, M.,Spencer, J.R.,Katz, B.A.,Yu, C.,Rai, R.,Young, W.B.,Schultz, B.,Janc, J. Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg.Med.Chem.Lett., 16:2796-2799, 2006 Cited by PubMed: 16487703DOI: 10.1016/j.bmcl.2006.01.123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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