2FK2
Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound
Summary for 2FK2
Entry DOI | 10.2210/pdb2fk2/pdb |
Related | 1OWT 2FJZ 2FK1 2FK3 |
Descriptor | Amyloid beta A4 protein precursor, COPPER (I) ION (3 entities in total) |
Functional Keywords | alpha-beta two-layered sandwich, cu(i) coordination, apoptosis |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 1 |
Total formula weight | 6912.47 |
Authors | Kong, G.K.-W.,Parker, M.W. (deposition date: 2006-01-03, release date: 2007-01-16, Last modification date: 2023-08-30) |
Primary citation | Kong, G.K.,Adams, J.J.,Harris, H.H.,Boas, J.F.,Curtain, C.C.,Galatis, D.,Masters, C.L.,Barnham, K.J.,McKinstry, W.J.,Cappai, R.,Parker, M.W. Structural Studies of the Alzheimer's Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions J.Mol.Biol., 367:148-161, 2007 Cited by PubMed: 17239395DOI: 10.1016/j.jmb.2006.12.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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