2FJN

The structure of phosphotyrosine phosphatase 1B in complex with compound 2

2FJN の概要

• エントリーDOI: 10.2210/pdb2fjn/pdb
• 関連するPDBエントリー: 2FJM
• 分子名称: Tyrosine-protein phosphatase, non-receptor type 1, CHLORIDE ION, (4-{(2S,4E)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-[4-(METHOXYCARBONYL)PHENYL]-5-PHENYLPENT-4-ENYL}PHENYL)(DIFLUORO)METHYLPHOSPHONIC ACID, ... (4 entities in total)
• 機能のキーワード: phosphatase, secondary binding site, selectivity, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73754.35

構造登録者

Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G. (登録日: 2006-01-03, 公開日: 2006-01-17, 最終更新日: 2023-08-30)

• 主引用文献: Asante-Appiah, E.,Patel, S.,Desponts, C.,Taylor, J.M.,Lau, C.,Dufresne, C.,Therien, M.,Friesen, R.,Becker, J.W.,Leblanc, Y.,Kennedy, B.P.,Scapin, G.; Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.; J.Biol.Chem., 281:8010-8015, 2006; PubMed: 16407290; DOI: 10.1074/jbc.M511827200

実験手法

X-RAY DIFFRACTION (2.2 Å)