2FHI

SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT

Summary for 2FHI

Entry DOI	10.2210/pdb2fhi/pdb
Descriptor	FRAGILE HISTIDINE TRIAD PROTEIN, P1-P2-METHYLENE-P3-THIO-DIADENOSINE TRIPHOSPHATE (3 entities in total)
Functional Keywords	nucleotide-binding protein, cancer, diadenosine triphosphate hydrolase, active site substitution, histidine triad, tumor suppressor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P49789
Total number of polymer chains	1
Total formula weight	17632.66
Authors	Pace, H.C.,Garrison, P.N.,Robinson, A.K.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Heubner, K.,Brenner, C. (deposition date: 1998-04-01, release date: 1998-06-17, Last modification date: 2023-08-09)
Primary citation	Pace, H.C.,Garrison, P.N.,Robinson, A.K.,Barnes, L.D.,Draganescu, A.,Rosler, A.,Blackburn, G.M.,Siprashvili, Z.,Croce, C.M.,Huebner, K.,Brenner, C. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proc.Natl.Acad.Sci.USA, 95:5484-5489, 1998 Cited by PubMed: 9576908 DOI: 10.1073/pnas.95.10.5484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation