2FGU
X-ray crystal structure of HIV-1 Protease T80S variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.
Summary for 2FGU
Entry DOI | 10.2210/pdb2fgu/pdb |
Related | 2FGV |
Descriptor | Protease, PHOSPHATE ION, quinoline-2-carboxylic acid, ... (8 entities in total) |
Functional Keywords | hiv protease, drug resistance, enzyme kinetics, sequence conservation, protein structure, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22793.23 |
Authors | Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Schiffer, C.A. (deposition date: 2005-12-22, release date: 2006-11-07, Last modification date: 2023-08-30) |
Primary citation | Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Henderson, G.J.,Harris, J.,Swanstrom, R.,Schiffer, C.A. Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity. J.Virol., 80:6906-6916, 2006 Cited by PubMed: 16809296DOI: 10.1128/JVI.01900-05 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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