2FGI

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074

Summary for 2FGI

Entry DOI	10.2210/pdb2fgi/pdb
Descriptor	PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA (3 entities in total)
Functional Keywords	protein kinase, tyrosine-protein kinase, atp-binding, phosphorylation, inhibitor, transferase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P11362
Total number of polymer chains	2
Total formula weight	71664.57
Authors	Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R. (deposition date: 1998-09-15, release date: 1999-09-13, Last modification date: 2023-12-27)
Primary citation	Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.C.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R. Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J., 17:5896-5904, 1998 Cited by PubMed: 9774334 DOI: 10.1093/emboj/17.20.5896 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation