2FGI

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074

2FGI の概要

• エントリーDOI: 10.2210/pdb2fgi/pdb
• 分子名称: PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1), 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA (3 entities in total)
• 機能のキーワード: protein kinase, tyrosine-protein kinase, atp-binding, phosphorylation, inhibitor, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P11362
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71664.57

構造登録者

Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R. (登録日: 1998-09-15, 公開日: 1999-09-13, 最終更新日: 2023-12-27)

• 主引用文献: Mohammadi, M.,Froum, S.,Hamby, J.M.,Schroeder, M.C.,Panek, R.L.,Lu, G.H.,Eliseenkova, A.V.,Green, D.,Schlessinger, J.,Hubbard, S.R.; Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.; EMBO J., 17:5896-5904, 1998; PubMed: 9774334; DOI: 10.1093/emboj/17.20.5896

実験手法

X-RAY DIFFRACTION (2.5 Å)