2FFH

THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS

2FFH の概要

• エントリーDOI: 10.2210/pdb2ffh/pdb
• 関連するPDBエントリー: 1FFH
• 分子名称: PROTEIN (FFH), CADMIUM ION, SULFATE ION (3 entities in total)
• 機能のキーワード: ffh, srp54, signal recognition particle, gtpase, m domain, rna-binding, signal sequence-binding, helix-turn-helix, protein targeting, protein transport
• 由来する生物種: Thermus aquaticus
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 142521.11

構造登録者

Keenan, R.J.,Freymann, D.M.,Walter, P.,Stroud, R.M. (登録日: 1999-06-29, 公開日: 1999-07-16, 最終更新日: 2023-08-30)

主引用文献

Keenan, R.J.,Freymann, D.M.,Walter, P.,Stroud, R.M.
Crystal structure of the signal sequence binding subunit of the signal recognition particle.
Cell(Cambridge,Mass.), 94:181-191, 1998

PubMed Abstract: The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.

PubMed: 9695947
DOI: 10.1016/S0092-8674(00)81418-X

実験手法

X-RAY DIFFRACTION (3.2 Å)