2FCI
Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
Summary for 2FCI
| Entry DOI | 10.2210/pdb2fci/pdb |
| Descriptor | Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350, C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759 (2 entities in total) |
| Functional Keywords | sh2 domain, phosphopeptide, syk kinase, plcgamma, plcc, hydrolase |
| Biological source | Bos taurus (cattle) More |
| Cellular location | Cell projection, lamellipodium (By similarity): P08487 |
| Total number of polymer chains | 2 |
| Total formula weight | 13975.43 |
| Authors | Groesch, T.D.,Zhou, F.,Mattila, S.,Geahlen, R.L.,Post, C.B. (deposition date: 2005-12-12, release date: 2006-01-31, Last modification date: 2023-11-15) |
| Primary citation | Groesch, T.D.,Zhou, F.,Mattila, S.,Geahlen, R.L.,Post, C.B. Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase J.Mol.Biol., 356:1222-1236, 2006 Cited by PubMed: 16410013DOI: 10.1016/j.jmb.2005.11.095 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
