2FCI

Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase

2FCI の概要

• エントリーDOI: 10.2210/pdb2fci/pdb
• 分子名称: Doubly phosphorylated peptide derived from Syk kinase comprising residues 338-350, C-termainl SH2 domain from phospholipase C-gamma-1 comprising residues 663-759 (2 entities in total)
• 機能のキーワード: sh2 domain, phosphopeptide, syk kinase, plcgamma, plcc, hydrolase
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cell projection, lamellipodium (By similarity): P08487
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13975.43

構造登録者

Groesch, T.D.,Zhou, F.,Mattila, S.,Geahlen, R.L.,Post, C.B. (登録日: 2005-12-12, 公開日: 2006-01-31, 最終更新日: 2023-11-15)

• 主引用文献: Groesch, T.D.,Zhou, F.,Mattila, S.,Geahlen, R.L.,Post, C.B.; Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by syk tyrosine kinase; J.Mol.Biol., 356:1222-1236, 2006; PubMed: 16410013; DOI: 10.1016/j.jmb.2005.11.095

実験手法

SOLUTION NMR